What is Creatine? Unlocking the Power of This Performance Enhancer

Creatine is one of the most popular and well-researched supplements in the sports and fitness world. But what exactly is creatine, and why is it so widely used? This article delves into the science behind creatine, exploring its benefits, uses, and safety to provide a comprehensive understanding of “Creatine What.”

Creatine is a naturally occurring compound found in muscle cells. It plays a crucial role in energy production, particularly during high-intensity, short-duration activities like weightlifting and sprinting. Understanding creatine’s function at a cellular level is key to appreciating its ergogenic potential.

Image: Chemical structure of creatine molecule, illustrating its composition and natural occurrence in the body.

What Does Creatine Do?

At its core, creatine helps regenerate adenosine triphosphate (ATP), the primary energy currency of cells. During intense exercise, ATP is rapidly depleted. Creatine phosphate, stored in muscles, donates a phosphate group to ADP (adenosine diphosphate) to quickly replenish ATP. This enhanced ATP availability allows for:

• Increased Muscle Strength and Power: Studies consistently show that creatine supplementation boosts strength and power output. For instance, research by Bemben MG et al. (2001) demonstrated improved muscle strength gains in college football athletes during resistance training when using creatine. Similarly, a study by Brose A et al. (2003) found enhanced isometric strength in older adults combining creatine with strength training.
• Enhanced High-Intensity Exercise Performance: Creatine is particularly effective for activities involving repeated bursts of high intensity. Research by Balsom PD et al. (1993) indicated creatine supplementation aids in dynamic high-intensity intermittent exercise. Ahmun RP et al. (2005) also highlighted its positive effects on multiple sprint cycling and running performance in rugby players.
• Muscle Growth (Hypertrophy): Beyond immediate performance gains, creatine contributes to long-term muscle growth. Volek JS et al. (1999) showed that creatine supplementation alongside heavy resistance training leads to significant muscle fiber adaptations. Burke DG et al. (2001) further supported this, finding increased lean tissue mass when whey protein and creatine were combined with resistance training.

Beyond Physical Performance: Potential Health Benefits

While primarily known for its performance-enhancing effects, research suggests creatine may offer broader health benefits:

• Cognitive Function: Emerging research explores creatine’s role in brain function. Rae C et al. (2003) found that oral creatine supplementation improved brain performance in a double-blind, placebo-controlled trial, suggesting potential cognitive benefits, especially in tasks requiring short-term memory and intelligence. Avgerinos KI et al. (2018) conducted a systematic review confirming creatine’s positive impact on cognitive function in healthy individuals.
• Therapeutic Applications: Creatine is being investigated for therapeutic use in various conditions. Studies have examined its effects on muscular dystrophy (Tarnopolsky MA et al., 2004), Parkinson’s disease (Bender A et al., 2006), and other neuromuscular disorders (Kley RA et al., 2011). While research is ongoing, these studies indicate potential therapeutic avenues for creatine.
• Blood Sugar Control: Alves CR et al. (2012) investigated creatine’s role in glucose uptake in type 2 diabetes, suggesting a possible link between creatine and improved glucose metabolism, potentially through AMPK-alpha activation. Gualano B et al. (2008) also explored creatine’s effects on glucose tolerance and insulin sensitivity in healthy males undergoing aerobic training.

Types of Creatine: What Form is Best?

Creatine monohydrate is the most extensively studied and widely used form of creatine. It is cost-effective and has proven efficacy. While other forms exist, such as creatine ethyl ester and creatine hydrochloride, they lack the robust scientific backing of creatine monohydrate. Gill ND et al. (2004) directly compared creatine serum to creatine powder and found creatine powder (monohydrate) to be more effective for improving cycle sprint performance.

Dosage and Usage: How to Take Creatine

A common creatine supplementation protocol involves a loading phase followed by a maintenance phase:

• Loading Phase: 20 grams per day for 5-7 days (typically 5 grams taken four times daily). This rapidly saturates muscle creatine stores.
• Maintenance Phase: 3-5 grams per day to maintain elevated muscle creatine levels.

Timing is less critical than consistent daily intake. Creatine can be taken anytime, although some prefer post-workout consumption. Green AL et al. (1996a, 1996b) found that carbohydrate ingestion can enhance creatine retention, suggesting taking creatine with a meal containing carbohydrates might be beneficial.

Is Creatine Safe? Addressing Concerns

Creatine has been rigorously studied for safety, and numerous studies confirm its safety for healthy individuals when used as recommended. Groeneveld GJ et al. (2005) in a placebo-controlled trial noted few adverse effects with long-term creatine supplementation. Gualano B et al. (2011) specifically showed that creatine supplementation does not impair kidney function in type 2 diabetic patients, and Lugaresi R et al. (2013) reached a similar conclusion in resistance-trained individuals consuming a high-protein diet, addressing kidney function concerns.

Common myths and unfounded concerns about creatine include:

• Kidney Damage: Extensive research has debunked this claim in healthy individuals with normal kidney function (Poortmans JR and Francaux M, 1999).
• Dehydration and Muscle Cramps: Lopez RM et al. (2009) in a systematic review with meta-analyses concluded that creatine supplementation does not hinder exercise heat tolerance or hydration status. Chang CT et al. (2002) even found creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis.
• Gastrointestinal Distress: While some individuals might experience mild gastrointestinal upset, Ostojic SM and Ahmetovic Z. (2008) suggested these side effects might be dose-dependent.

Who Can Benefit from Creatine?

Creatine supplementation is beneficial for a wide range of individuals:

• Athletes and Bodybuilders: To enhance strength, power, and muscle mass.
• Individuals Engaging in High-Intensity Exercise: To improve performance in activities like sprinting, HIIT training, and team sports.
• Older Adults: To combat age-related muscle loss and maintain strength (Candow DG et al., 2014).
• Vegetarians and Vegans: Vegetarians often have lower muscle creatine levels, making them potentially more responsive to supplementation (Shomrat A et al., 2000).

Conclusion: Creatine – A Powerful and Safe Supplement

Creatine is a scientifically supported supplement that offers significant benefits for enhancing physical performance and potentially supporting cognitive and therapeutic applications. When used responsibly and with proper dosage, creatine is a safe and effective tool to unlock your performance potential. Understanding “creatine what” empowers you to make informed decisions about incorporating this supplement into your fitness or health regimen.

References

• Aaserud, R., Gramvik, P., Olsen, S. R., and Jensen, J. Creatine supplementation delays onset of fatigue during repeated bouts of sprint running. Scand.J Med Sci.Sports 1998;8(5 Pt 1):247-251.
• Ahmun, R. P., Tong, R. J., and Grimshaw, P. N. The effects of acute creatine supplementation on multiple sprint cycling and running performance in rugby players. J Strength.Cond.Res 2005;19(1):92-97.
• Alves, C. R., Ferreira, J. C., de Siqueira-Filho, M. A., Carvalho, C. R., Lancha, A. H., Jr., and Gualano, B. Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-alpha? Amino.Acids 2012;43(4):1803-1807.
• Avgerinos KI, Spyrou N, Bougioukas KI, Kapogiannis D. Effects of creatine supplementation on cognitive function of healthy individuals: A systematic review of randomized controlled trials. Exp Gerontol. 2018;108:166-173.
• Balsom PD, Ekblom B, Soderlund K, and et al. Creatine supplementation and dynamic high-intensity intermittent excercise. Scand J Med Sci Sports 1993;3:143-149.
• Bemben MG, Bemben DA, Loftiss DD, and Knehans AW. Creatine supplementation during resistance training in college football athletes. Med Sci.Sports Exerc. 2001;33(10):1667-1673.
• Bender A, Koch W, Elstner M, et al. Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial. Neurology 2006;67:1262-4.
• Brose, A., Parise, G., and Tarnopolsky, M. A. Creatine supplementation enhances isometric strength and body composition improvements following strength exercise training in older adults. J Gerontol A Biol.Sci.Med Sci. 2003;58(1):11-19.
• Burke, D. G., Chilibeck, P. D., Davidson, K. S., Candow, D. G., Farthing, J., and Smith-Palmer, T. The effect of whey protein supplementation with and without creatine monohydrate combined with resistance training on lean tissue mass and muscle strength. Int J Sport Nutr.Exerc.Metab 2001;11(3):349-364.
• Candow DG, Chilibeck PD, Forbes SC. Creatine supplementation and aging musculoskeletal health. Endocrine 2014;45(3):354-61.
• Chang, C. T., Wu, C. H., Yang, C. W., Huang, J. Y., and Wu, M. S. Creatine monohydrate treatment alleviates muscle cramps associated with haemodialysis. Nephrol.Dial.Transplant. 2002;17(11):1978-1981.
• Gill, N. D., Hall, R. D., and Blazevich, A. J. Creatine serum is not as effective as creatine powder for improving cycle sprint performance in competitive male team-sport athletes. J Strength.Cond.Res 2004;18(2):272-275.
• Green, A. L., Hultman, E., Macdonald, I. A., et al. Carbohydrate ingestion augments skeletal muscle creatine accumulation during creatine supplementation in humans. Am J Physiol 1996a;271:E821-6.
• Green, A. L., Simpson, E. J., Littlewood, J. J., et al. Carbohydrate ingestion augments creatine retention during creatine feeding in humans. Acta Physiol Scand 1996b;158:195-202.
• Groeneveld, G. J., Beijer, C., Veldink, J. H., Kalmijn, S., Wokke, J. H., and van den Berg, L. H. Few adverse effects of long-term creatine supplementation in a placebo-controlled trial. Int J Sports Med 2005;26(4):307-313.
• Gualano, B., de, Salles Painelli, V, Roschel, H., Lugaresi, R., Dorea, E., Artioli, G. G., Lima, F. R., da Silva, M. E., Cunha, M. R., Seguro, A. C., Shimizu, M. H., Otaduy, M. C., Sapienza, M. T., da Costa, Leite C., Bonfa, E., and Lancha Junior, A. H. Creatine supplementation does not impair kidney function in type 2 diabetic patients: a randomized, double-blind, placebo-controlled, clinical trial. Eur.J.Appl.Physiol 2011;111(5):749-756.
• Gualano, B., Novaes, R. B., Artioli, G. G., Freire, T. O., Coelho, D. F., Scagliusi, F. B., Rogeri, P. S., Roschel, H., Ugrinowitsch, C., and Lancha, A. H., Jr. Effects of creatine supplementation on glucose tolerance and insulin sensitivity in sedentary healthy males undergoing aerobic training. Amino.Acids 2008;34(2):245-250.
• Kley, R. A., Tarnopolsky, M. A., and Vorgerd, M. Creatine for treating muscle disorders. Cochrane.Database.Syst.Rev. 2011;(2):CD004760.
• Lopez, R. M., Casa, D. J., McDermott, B. P., Ganio, M. S., Armstrong, L. E., and Maresh, C. M. Does creatine supplementation hinder exercise heat tolerance or hydration status? A systematic review with meta-analyses. J.Athl.Train. 2009;44(2):215-223.
• Lugaresi, R., Leme, M., de, Salles Painelli, V, Murai, I. H., Roschel, H., Sapienza, M. T., Lancha Junior, A. H., and Gualano, B. Does long-term creatine supplementation impair kidney function in resistance-trained individuals consuming a high-protein diet? J.Int.Soc.Sports Nutr. 2013;10(1):26.
• Ostojic, S. M. and Ahmetovic, Z. Gastrointestinal distress after creatine supplementation in athletes: are side effects dose dependent? Res.Sports Med. 2008;16(1):15-22.
• Poortmans, J. R. and Francaux, M. Long-term oral creatine supplementation does not impair renal function in healthy athletes. Med Sci Sports Exerc 1999;31:1108-10.
• Rae, C., Digney, A. L., McEwan, S. R., and Bates, T. C. Oral creatine monohydrate supplementation improves brain performance: a double-blind, placebo-controlled, cross-over trial. Proc Biol Sci 10-22-2003;270(1529):2147-2150.
• Shomrat, A., Weinstein, Y., and Katz, A. Effect of creatine feeding on maximal exercise performance in vegetarians. Eur.J Appl.Physiol 2000;82(4):321-325.
• Tarnopolsky, M. A., Mahoney, D. J., Vajsar, J., Rodriguez, C., Doherty, T. J., Roy, B. D., and Biggar, D. Creatine monohydrate enhances strength and body composition in Duchenne muscular dystrophy. Neurology 5-25-2004;62(10):1771-1777.
• Volek, J. S., Duncan, N. D., Mazzetti, S. A., Staron, R. S., Putukian, M., Gomez, A. L., Pearson, D. R., Fink, W. J., and Kraemer, W. J. Performance and muscle fiber adaptations to creatine supplementation and heavy resistance training. Med Sci.Sports Exerc. 1999;31(8):1147-1156.